Looking at the tweet below I expect Löw's starting line-up for Russia2018 to be:
Neuer (if fit) - Kimmich, Boateng, Hummels, Hector - Khedira, Kroos - Müller, Özil, Reus (if fit) - Werner.
Seeing Löw is quite loyal, and conservative when it comes to bedding in youngsters/new faces, I'm expecting P. Max doesn't stand a chance. IMHO, a mistake. If Kimmich is injured/dip in form/serving a suspension/... a CB or Can probably will have to cover. The fullbacks, starters/cover, seem to be a bigger woe than the CBs again. In the tweet you can see how great Germany's depth is except at fullback/wingback (Henrichs probably won't make the final 23). As Löw has used wingbacks (in friendlies, the Confed. Cup, etc.) P. Max could have been a great addition (even more assists/game at LWB). Sané could also be a LWB option but it's a pretty hard position to get right (and you need an extra set of lungs to get up and down the pitch). Should have selected Hector and Max (instead of Plattenhardt).
Löw has made his fullbacks responsible for providing width in a possession-based system, while wingers play more centrally as inverted playmaking wingers (the likes of Reus, Götze, Özil, Draxler, Müller, et al. have been used like that for years). If fit I'm guessing Reus starts on the left and Sané could even be 3rd choice behind Draxler. Then Özil and Müller are nailed on starters for Löw. As depth on the right isn't as good as it seems in the tweet Sané probably has more of a chance there (2nd choice, behind Müller). Sané will most likely be the biggest victim of how Löw likes to set up Germany. On form this season I'd say Sané deserves to be in the starting line-up yet I doubt Löw will start him/go with a system more suited to Sané.
It's unlikely Germany will struggle much in their build-up play, and to a lesser extent when transitioning from defending to attacking, however they could struggle a bit more when having to transition from attack to defence. There's not that much Fingerspitzengefühl, especially for the holding role. Khedira and Kroos having to snuff out danger time and again is a bit of a gamble. The other big ? is how Werner will fare. He'll have to be more clinical because he won't get as many chances in Russia and he's inexperienced at this level. OTOH Germany shares the goals around and they have plenty of players that know how to find the back of the net.
@Der Chefscout @-JMH- your thoughts, please.